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apalutamide will decrease the level or impact of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with medications that happen to be CYP2C19 substrates may end up in reduce exposure to these prescription drugs.fluvoxamine will raise the degree or effe